2023

Piperacillin Steady State Concentrations in Target Tissues Relevant for PJI Treatment—A Randomized Porcine Microdialysis Study Comparing Continuous Infusion with Intermittent Short-Term Infusion.  

Rasmussen, H.C.; Hanberg, P.; Knudsen, M.; Tøstesen, S.K.; Jørgensen, A.R.; Petersen, E.K.; Öbrink-Hansen, K.; Søballe, K.; Stilling, M.; Bue, M.

Antibiotics 2023, 12, 577. doi.org/10.3390/antibiotics12030577 

2022 

Intermittent short-term infusion vs. continuous infusion of piperacillin: steady state concentrations in porcine cervical spine tissue evaluated by microdialysis. 

Petersen EK, Hanberg P, Knudsen M, Tøstesen SK, Jørgensen AR, Öbrink-Hansen K, Søballe K, Stilling M, Bue M. 

Antibiotics. 2022; 11(7):910. doi.org/10.3390/antibiotics11070910 

Subtherapeutic levels of cefuroxime inside a cannulated pedicle screw used in spine surgery: results from a porcine microdialysis study.  

Hvistendahl MA, Hanberg P, Stilling M, Kaspersen AE, Høy K, Bue M. 

Acta Orthop. 2022 Nov 28;93:874-879.  

doi: 10.2340/17453674.2022.5276. PMID: 36445157; PMCID: PMC9707378. 

Population Pharmacokinetics of Flucloxacillin In Bone and Soft Tissue- Standard Dosing is Not Sufficient to Achieve Therapeutic Concentrations.

Öbrink-Hansen K, Pham AD, Bue M, Hanberg P, Bendtsen M, Slater J, Friberg LE, Thorsted A, Stilling M.

Pharm Res. 2022 Mar 1. doi: 10.1007/s11095-022-03197-y. Online ahead of print.

PMID: 35233728

Abdominal tissue concentrations and penetration of carboplatin in a HIPEC procedure ‒ assessment in a novel porcine model. 

Petersen EK, Bue M, Harlev C, Jørgensen AR, Schmedes A, Hanberg P, Petersen LK, Stilling M.  

Pleura and Peritoneum. 2022 June;7(3) - Epub ahead of print 
doi: 10.1515/pp-2022-0110 

Cefuroxime concentrations in the anterior and posterior column of the lumbar spine - an experimental porcine study 

Hvistendahl MA, Bue M, Hanberg P, Kaspersen AE, Schmedes AV, Stilling M, Høy K. 

Spine J 2022; 10.1016/j.spinee.2022.05.010  

2022 Jun 4; 

doi: 10.1016/j.spinee.2022.05.010. Online ahead of print. 

Tibial bone and soft-tissue concentrations following combination therapy with vancomycin and meropenem - evaluated by microdialysis in a porcine model: should patients with open fractures have higher doses of antibiotics?  

Vittrup SØ, Hanberg P, Knudsen MB, Tøstesen SK, Kipp JO, Hansen J, Jørgensen NP, Stilling M, Bue M.  

Bone Joint Res. 2022 Feb;11(2):112-120.  

doi: 10.1302/2046-3758.112.BJR-2021-0321.R1. PMID: 35176868; PMCID: PMC8882321. 

High Cefuroxime Concentrations and Long Elimination in an Orthopaedic Surgical Deadspace-A Microdialysis Porcine Study.

Tøstesen SK, Stilling M, Hanberg P, Thillemann TM, Falstie-Jensen T, Tøttrup M, Knudsen M, Petersen ET, Bue M.

Antibiotics (Basel). 2022 Feb 7;11(2):208. doi: 10.3390/antibiotics11020208.

PMID: 35203810

Weight-based cefuroxime dosing provides comparable orthopedic target tissue concentrations between weight groups - a microdialysis porcine study.

Tøstesen SK, Hanberg P, Bue M, Thillemann TM, Falstie-Jensen T, Tøttrup M, Knudsen MB, Schmedes AV, Stilling M.

APMIS. 2022 Feb;130(2):111-118. doi: 10.1111/apm.13198. Epub 2021 Dec 22.

PMID: 34862642

Moxifloxacin Concentrations in the Knee Joint, Tibial Bone, and Soft Tissue when Combined with Rifampicin: A Randomized Porcine Study 

Slater J, Stilling M, Hanberg P, Fichtner Bendtsen MA, Jørgensen AR, Søballe K, Bue M

J Bone Joint Surg Am. 2022  Jan 5;104(1):49-54. doi: 10.2106/JBJS.21.00549.PMID: 34731098

2021  

Effects of tourniquet inflation on peri- and postoperative cefuroxime concentrations in bone and tissue. 

Hanberg P, Bue M, Kabel J, Jørgensen AR, Jessen C, Søballe K, Stilling M.   

Acta Orthop. 2021 Dec;92(6):746-752. doi: 10.1080/17453674.2021.1942620. Epub 2021 Aug 2.PMID: 34334093 

Evaluation of Benzylpenicillin as an Internal Standard for Measurement of Piperacillin Bone Concentrations Via  

Microdialysis.  

Knudsen M, Bue M, Pontoppidan LL, Hvistendahl MA, Søballe K, Stilling M, Hanberg P.  

J Pharm Sci. 2021 Jun 5:S0022-3549(21)00298-7.  

doi: 10.1016/j.xphs.2021.06.008.  

Flucloxacillin bone and soft tissue concentrations assessed by microdialysis in pigs after intravenous and oral  

administration.  

Bendtsen MAF, Bue M, Hanberg P, Slater J, Thomassen MB, Hansen J, Søballe K, Öbrink-Hansen K, Stilling M.  

Bone Joint Res. 2021 Jan;10(1):60-67.  

doi: 10.1302/2046-3758.101.BJR-2020-0250.R1. 

Vancomycin bone and tissue concentrations following tibial intraosseous administration - evaluated in a porcine  

model.  

Olsen Kipp J, Hanberg P, Slater J, Møller Nielsen L, Storgaard Jakobsen S, Stilling M, Bue M. 

J Bone Jt Infect. 2021 Feb 12;6(4):99-106.  

doi: 10.5194/jbji-6-99-2021. 

Influence of anastomoses on intestine ischemia and cefuroxime concentrations: Evaluated in the ileum and colon in  
a porcine model. 

Hanberg P, Bue M, Thomassen M, Løve US, Kipp JO, Harlev C, Petersen E, Søballe K, Stilling M. 

World J Gastrointest Pathophysiol. 2021 Jan 22;12(1):1-13.  

doi: 10.4291/wjgp.v12.i1.1. 

Double-dose cefuroxime concentrations in bone, synovial fluid of the knee joint and subcutaneous adipose tissue-A  
randomised porcine microdialysis study. 

Jørgensen AR, Hanberg P, Bue M, Thomassen MB, Pedersen Jørgensen N, Stilling M. 

Eur J Pharm Sci. 2021 May 1;160:105754. Epub 2021 Feb 12. 

doi: 10.1016/j.ejps.2021.105754. 

Tourniquet-induced ischemia and reperfusion in subcutaneous tissue, skeletal muscle, and calcaneal cancellous  
bone. 

Hanberg P, Bue M, Kabel J, Jørgensen AR, Søballe K, Stilling M. 

APMIS. 2021 Apr;129(4):225-231. Epub 2021 Feb 23. 

doi: 10.1111/apm.13121. 

2020  

Inflammatory proteins in infected bone tissue - an explorative porcine study. 

Bue M, Bergholt NL, Jensen LK, Jensen HL, Søballe K, Stilling M, Hanberg P.  

Bone Reports 2020, June 26;13:100292.  

doi: 10.1016/j.bonr.2020.100292 

Timing of Antimicrobial Prophylaxis and Tourniquet inflation - A Randomized Controlled Microdialysis Study. 

Hanberg P, Bue Mats, Öbrink-Hansen KM, Thomassen MB, Søballe K, Stilling M. 

Journal Bone Joint Surgery 2020, Nov 4;102(21):1857-1864. Aug 4 [Epub]. 

doi: 10.2106/JBJS.20.00076 

Effects of rifampicin on moxifloxacin concentrations in porcine cervical spine: A randomised microdialysis study. 

Slater J; Hanberg P; Bendtsen MAF; Jørgensen AR; Greibe E; Søballe K; Bue M; Jørgensen NP; Stilling M.         
J Antimicrob Chemother. 2020 Aug 1;75(8):2206-2212. May 15 [Epub]. 

doi: 10.1093/jac/dkaa153 

Pharmacokinetics of a double-dose cefuroxime in porcine intervertebral disc and vertebral cancellous bone – A randomized microdialysis study. 

Hanberg P, Bue M, Jørgensen AR, Thomassen M, Öbrink-Hansen K, Søballe K, Stilling M. 

Spine J. 2020 Mar 16. [Epub]. 

doi: 10.1016/j.spinee.2020.03.006. 

Microdialysis for the Assessment of Intervertebral Disc and Vertebral Cancellous Bone Metabolism in a Large Porcine Model.  

Bue M, Hanberg P, Thomassen MB, Tøttrup M, Thillemann TM, Søballe K, Birke-Sørensen H.  

In Vivo. 2020 Mar-Apr;34(2):527-532.  

doi: 10.21873/invivo.11804. 

Population pharmacokinetics of piperacillin in plasma and subcutaneous tissue in patients on continuous renal replacement therapy.  

Bue M, Sou T, Okkels ASL, Hanberg P, Thorsted A, Friberg LE, Andersson TL, Öbrink-Hansen K, Christensen S.  

Int J Infect Dis. 2020 Mar;92:133-140.  

doi: 10.1016/j.ijid.2020.01.010. 

Local concentrations of gentamicin obtained by microdialysis after a controlled application of a GentaColl sponge in a porcine model.  

Thomassen MB, Hanberg P, Stilling M, Petersen KK, Søballe K, Krag LB, Højskov CS, Bue M.  

J Orthop Res. 2020 Aug;38(8):1793-1799.  

doi: 10.1002/jor.24588. 

2019 

Local Vancomycin Concentrations after Intra-articular Injection into the Knee Joint: An Experimental Porcine Study. 

Bue M, Thomassen MB, Larsen OH, Jørgensen AR, Stilling M, Søballe K, Hanberg P. 

J Knee Surg. 2019 Dec 30. [Epub]. 
doi: 10.1055/s-0039-3402078. 

Simultaneous Retrodialysis by Drug for Cefuroxime Using Meropenem as an Internal Standard-A Microdialysis Validation Study. 

Hanberg P, Bue M, Öbrink-Hansen K, Kabel J, Thomassen M, Tøttrup M, Søballe K, Stilling M. 

J Pharm Sci. 2019 Nov 20. [Epub]. 

doi: 10.1016/j.xphs.2019.11.014. 

Bone, subcutaneous tissue and plasma pharmacokinetics of cefuroxime in total knee replacement patients - a randomized controlled trial comparing continuous and short-term infusion.  

Tøttrup M, Søballe K, Bibby BM, Hardlei TF, Hansen P, Fuursted K, Birke-Sørensen H, Bue M.  

APMIS. 2019 Dec;127(12):779-788.  

doi: 10.1111/apm.12996. 

Single-dose pharmacokinetics of meropenem in porcine cancellous bone determined by microdialysis: An animal study.  

Hanberg P, Lund A, Søballe K, Bue M.  

Bone Joint Res. 2019 Aug 2;8(7):313-322.  

doi: 10.1302/2046-3758.87.BJR-2018-0308.R1. 

2018 

Vancomycin concentrations in the cervical spine after intravenous administration: results from an experimental pig study.  

Bue M, Hanberg P, Tøttrup M, Thomassen MB, Birke-Sørensen H, Thillemann TM, Andersson TL, Søballe K. 

Acta Orthop. 2018 Dec;89(6):683-688.  

doi: 10.1080/17453674.2018.1501548.  

Population Pharmacokinetics of Meropenem in Plasma and Subcutis from Patients on Extracorporeal Membrane Oxygenation Treatment.  

Hanberg P, Öbrink-Hansen K, Thorsted A, Bue M, Tøttrup M, Friberg LE, Hardlei TF, Søballe K, Gjedsted J  

Antimicrob Agents Chemother. 2018 Apr 26;62(5):e02390-17.  

doi: 10.1128/AAC.02390-17. 

Single-dose bone pharmacokinetics of vancomycin in a porcine implant-associated osteomyelitis model. 

Bue M, Hanberg P, Koch J, Jensen LK, Lundorff M, Aalbaek B, Jensen HE, Søballe K, Tøttrup M.  

J Orthop Res. 2018 Apr;36(4):1093-1098.  

doi: 10.1002/jor.23776 

Bone and subcutaneous adipose tissue pharmacokinetics of vancomycin in total knee replacement patients.  

Bue M, Tøttrup M, Hanberg P, Langhoff O, Birke-Sørensen H, Thillemann TM, Andersson TL, Søballe K.  

Acta Orthop. 2018 Feb;89(1):95-100.  

doi: 10.1080/17453674.2017.1373497.  

2017 

Suppurative Inflammation and Local Tissue Destruction Reduce the Penetration of Cefuroxime to Infected Bone Implant Cavities.  

Jensen LK, Koch J, Henriksen NL, Bue M, Tøttrup M, Hanberg P, Søballe K, Jensen HE. 

J Comp Pathol. 2017 Nov;157(4):308-316.  

doi: 10.1016/j.jcpa.2017.10.001. 

2016 

Effects of Implant-Associated Osteomyelitis on Cefuroxime Bone Pharmacokinetics: Assessment in a Porcine Model. 

Tøttrup M, Bue M, Koch J, Jensen LK, Hanberg P, Aalbæk B, Fuursted K, Jensen HE, Søballe K.  

J Bone Joint Surg Am. 2016 Mar 2;98(5):363-9.  

doi: 10.2106/JBJS.O.00550. 

Pharmacokinetics of single-dose cefuroxime in porcine intervertebral disc and vertebral cancellous bone determined by microdialysis. 

Hanberg P, Bue M, Birke Sørensen H, Søballe K, Tøttrup M.  

Spine J. 2016 Mar;16(3):432-8.  

doi: 10.1016/j.spinee.2015.11.031. 

2015 

Continuous versus short-term infusion of cefuroxime: assessment of concept based on plasma, subcutaneous tissue, and bone pharmacokinetics in an animal model.  

Tøttrup M, Bibby BM, Hardlei TF, Bue M, Kerrn-Jespersen S, Fuursted K, Søballe K, Birke-Sørensen H.  

Antimicrob Agents Chemother. 2015 Jan;59(1):67-75.  

doi: 10.1128/AAC.03857-14. 

2014 

Pharmacokinetics of cefuroxime in porcine cortical and cancellous bone determined by microdialysis. 

Tøttrup M, Hardlei TF, Bendtsen M, Bue M, Brock B, Fuursted K, Søballe K, Birke-Sørensen H.   

Antimicrob Agents Chemother. 2014 Jun;58(6):3200-5.  

doi: 10.1128/AAC.02438-14.